This article refers briefly to the relation Thessaloniki has with Bulgarian, Serbian and Russian civilisation. Emphasis is given to the spread of the cult of St. Demetrius to the Slavic people and to the effect it has on their lives. In Russia, along with the cult of St. Demetrius, the worship of St. Alexander of Thessaloniki is widespread. Thessaloniki as an artistic Centre plays an important role in the civilization of Serbia during the Middle-Ages, while its relations with Bulgaria and Russia are periodic and casual.