In this article we focus on the evolution of the city and city planning in the Hellenistic era through the systematization of the major factors that have generate the urban rules. Therefore, we examine the effect of important historic, social and economical events, philosophical currents, political systems and arts, in particular architecture, on the built environment of the Hellenistic city. Thus, we attempt to exhalt the dynamic character of both the city and city planning through the mutual influence of the above variables.