The strength and endurance of art values and qualities are examined in this article, in relation with the place, time, circumstances and cultural provenance of the society in which they are developed. By comparing two completely different cases of artistic prime in the world art history, those of the Hellenistic period and Art Nouveau, a comparative study is attempted, on the basis of the sources that inspired their artists as well as their common thematic repertoire, elements which contributed to the formation of the style of these artistic trends. Through this study various conclusions are reached, which lead us to consider that the great values in art remain unchanged throughout the centuries, since they express the human spirit, soul and intellect, regardless of the period. The important creators of French Art Nouveau of the late nineteenth and the early twentieth century seem to stand, more or less, on the same aesthetic platform with their anonymous colleagues of the vast, in time, geographic and cultural extent, Hellenistic era. The various arguments and criticism concerning these two cultural trends, being as a rule controversial and ambiguous, are also presented in this article. Finally, their common route is recorded, by investigating both the impact of other civilizations on them and the common techniques that they have developed, accidentally or not.